Hazard Awareness and Management Manual (HAMM)
III. Laboratory Chemical Hygiene
4.0 Chemical Carcinogen Memorandum of Understanding and Agreement (CMUA)
4.0 Chemical Carcinogen Memorandum of Understanding and Agreement (CMUA)
The CMUA gives a PI or supervisor the authority to order, receive and use the select carcinogens specified in the CMUA.
All use of select carcinogens requires an approved CMUA. A select carcinogen is a chemical classified as:
1. Group 1, Carcinogenic to Humans, by the International Agency for Research on Cancer (IARC); or
2. A known carcinogen (KC) by the National Toxicology Program (NTP); or
3. A regulated carcinogen under the Washington Industrial Safety and Health Act (WISHA).
4.1 Application
When an investigator uses a select carcinogen for a project, a CMUA must be submitted to EH&S. To determine whether or not a CMUA is required, check
Table 12.11. CMUA and CMUA Amendment Forms are available electronically on the EH&S Website:centernet.fhcrc.org/CN/depts/ehs/forms.html
These forms are also available from EH&S directly.
The CMUA requests the following information:
1. Name of chemical carcinogen to be used;
2. Maximum volume to be used;
3. Brief description of the purpose for using the carcinogen;
4. Specific lab procedures to be followed;
5. Special instructions for use;
6. Personal protective equipment required;
7. Medical surveillance requirement;
8. Emergency contact information; and
9. Disposal Procedure.
4.2 Approval Criteria
All CMUA applications are reviewed by the Chemical Hygiene Officer (CHO) prior to approval. The following criteria must be met:
1. The CMUA is satisfactorily completed, signed, and returned to the CHO.
2. The appropriate PPE is listed and available.
3. The safety, spill clean-up, and disposal procedures are adequate.
4. Hazard awareness training has been provided to the staff listed on the CMUA. Each user must initial the form acknowledging having received such training.
Once approved, the investigator is authorized to use the specified select carcinogen(s) for a period of three years.
4.2.1 Amendments
Revisions to an existing CMUA must be submitted to EH&S on the CMUA Amendment Form. Contact EH&S for a copy of the form.
Amendments are required for the following circumstances:
1. A change, addition or deletion of a select carcinogen(s);
2. A change in labs or room numbers;
3. A change in procedure that would increase the risk of exposure to lab staff; or
4. The removal or addition of one or more staff members working with the chemical carcinogen.
4.2.2 Renewals
A CMUA can be amended for three years. At the end of three years, EH&S will ask the PI to submit a new CMUA form incorporating all the amendments from the previous three year period. EH&S will notify the PI prior to the expiration of the CMUA.
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